Article
Transient myeloproliferative disorder with partial trisomy 21.
Pediatric blood & cancer - 1 Nov 2015
Takahashi Takahide, Inoue Akira, Yoshimoto Junko, Kanamitsu Kiichiro, Taki Tomohiko, Imada Masahide, Yamada Mutsuko, Ninomiya Shinsuke, Toki Tsutomu, Terui Kiminori, Ito Etsuro, Shimada Akira
Abstract excerpt
Myeloid malignancy with Down syndrome (ML-DS) is estimated to have a step-wise leukemogenesis including GATA1 mutation. Trisomy 21 is essential for ML-DS; however, we do not know exactly which gene or genes located on chromosome 21 are necessary for the ML-DS. We report a female infant with transient myeloproliferative disorder (TMD) and partial trisomy 21. SNP array analysis showed 10 Mb amplification of...
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