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Clinical, cytogenetic, and molecular analyses of 17 neonates with transient abnormal myelopoiesis and nonconstitutional trisomy 21.

Pediatric blood & cancer - 1 Apr 2020

Yuzawa Kentaro, Terui Kiminori, Toki Tsutomu, Kanezaki Rika, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Kudo Ko, Sasaki Shinya, Endo Mikiya, Ozono Shuichi, Nomura Keiko, Ito Etsuro

Abstract excerpt

BACKGROUND: Transient abnormal myelopoiesis (TAM) is a unique myeloproliferative disorder that occurs in neonates with constitutional trisomy 21/Down syndrome (DS). Although TAM also develops in neonates without constitutional trisomy 21, the clinical, cytogenetic, and molecular characteristics of those patients are not fully understood. PROCEDURE: We retrospectively evaluated the clinical and cytogenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32020774
DOI: 10.1002/pbc.28188

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