Article
Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.
Blood - 15 Jan 2009
Kearney Lyndal, Gonzalez De Castro David, Yeung Jenny, Procter Julia, Horsley Sharon W, Eguchi-Ishimae Minenori, Bateman Caroline M, Anderson Kristina, Chaplin Tracy, Young Bryan D, Harrison Christine J, Kempski Helena, So Chi Wai E, Ford Anthony M, Greaves Mel
Abstract excerpt
Children with Down syndrome (DS) have a greatly increased risk of acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia (ALL). Both DS-AMKL and the related transient myeloproliferative disorder (TMD) have GATA1 mutations as obligatory, early events. To identify mutations contributing to leukemogenesis in DS-ALL, we undertook sequencing of candidate genes, including FLT3, RAS, PTPN11, BRAF, and...
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