Article
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.
Brain : a journal of neurology - 1 Sept 2015
Jucaite Aurelija, Svenningsson Per, Rinne Juha O, Cselényi Zsolt, Varnäs Katarina, Johnström Peter, Amini Nahid, Kirjavainen Anna, Helin Semi, Minkwitz Margaret, Kugler Alan R, Posener Joel A, Budd Samantha, Halldin Christer, Varrone Andrea, Farde Lars
Abstract excerpt
Impaired mitochondrial function, oxidative stress and formation of excessive levels of reactive oxygen species play a key role in neurodegeneration in Parkinson's disease. Myeloperoxidase is a reactive oxygen generating enzyme and is expressed by microglia. The novel compound AZD3241 is a selective and irreversible inhibitor of myeloperoxidase. The hypothesized mechanism of action of AZD3241 involves reduction of...
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