Article

Targeting myeloperoxidase to reduce neuroinflammation in X-linked dystonia parkinsonism

2024-06-25

Abstract excerpt

Although the genetic locus of X-linked dystonia parkinsonism (XDP), a neurodegenerative disease endemic in the Philippines, is well-characterized, the exact molecular mechanisms leading to neuronal loss are not yet fully understood. Recently, we demonstrated a significant increase in astrogliosis and microgliosis together with an increase in myeloperoxidase (MPO) levels in XDP post-mortem prefrontal cortex (PFC),...

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Literature Corpus work: 9ba6a35d-7e9e-53f2-b887-233bb97c8c0c
DOI: 10.1101/2024.06.25.24309481

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