Article
Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression.
Aging - 24 Jul 2020
Wang Yong, Wang Qian, Yu Ruobing, Zhang Qi, Zhang Zhonghai, Li Haiying, Ren Chao, Yang Rongli, Niu Haichen
Abstract excerpt
Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson's disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensive neuroinflammation of SN. However, it remains unclear as to whether microglia participate in the mαSyn pathology....
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