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Article

Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b.

Journal of medical virology - 1 Jan 2010

Kobayashi Mariko, Akuta Norio, Suzuki Fumitaka, Hosaka Tetsuya, Sezaki Hitomi, Kobayashi Masahiro, Suzuki Yoshiyuki, Arase Yasuji, Ikeda Kenji, Watahiki Sachiyo, Mineta Rie, Iwasaki Satomi, Miyakawa Yuzo, Kumada Hiromitsu

Abstract excerpt

The substitution of amino acid (aa) 70 of arginine for glutamine and/or that of aa91 of leucine for methionine in the core protein in patients infected with hepatitis C virus (HCV) genotype 1b is associated with a poor response to pegylated interferon and ribavirin. Factors influencing these substitutions were sought in 1,097 patients infected with HCV-1b who had not received antiviral treatment. HCV variants...

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Source

Identifiers

PMID: 19950230
DOI: 10.1002/jmv.21629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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