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Article

Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirin.

The Journal of infectious diseases - 1 Jun 2010

Kurbanov Fuat, Tanaka Yasuhito, Matsuura Kentaro, Sugauchi Fuminaka, Elkady Abeer, Khan Anis, Hasegawa Izumi, Ohno Tomoyoshi, Tokuda Hiroshi, Mizokami Masashi

Abstract excerpt

BACKGROUND: Approximately 20% of patients with hepatitis C virus (HCV) genotype 1b infection have nonresponse to the most current treatment, pegylated interferon with ribavirin. Mutations in the HCV core region were recently proposed to be associated with nonresponse. Our aim was to evaluate the viral factors associated with treatment failure. METHODS: HCV variants were determined directly and after cloning in 66...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20420509
DOI: 10.1086/652500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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