Article
Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2010
Tachi Yoshihiko, Katano Yoshiaki, Honda Takashi, Hayashi Kazuhiko, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Nakano Isao, Samejima Youichi, Goto Hidemi
Abstract excerpt
BACKGROUND: Liver steatosis and hepatic oxidative stress are the histopathological features of chronic hepatitis C. Hepatitis C virus (HCV) genotype 1 core protein induces hepatic steatosis and reactive oxygen species production in transgenic mice. The amino acid substitutions in the HCV core region appear to be related to hepatocarcinogenesis. AIMS: The aim of this study was to clarify the impact of mutations in...
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