Article
Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA.
Oncogene - 1 Mar 2021
Niu Guanglin, Hellmuth Isabel, Flisikowska Tatiana, Pausch Hubert, Rieblinger Beate, Carrapeiro Alexander, Schade Benjamin, Böhm Brigitte, Kappe Eva, Fischer Konrad, Klinger Bernhard, Steiger Katja, Burgkart Reiner, Bourdon Jean-Christophe, Saur Dieter, Kind Alexander, Schnieke Angelika, Flisikowski Krzysztof
Abstract excerpt
Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele that carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53R167H (orthologous to human TP53R175H) in exon 5. Pigs with the unrecombined mutant allele (flTP53R167H) develop mainly osteosarcoma but also...
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