Article

Porcine model elucidates function of p53 isoform in carcinogenesis

2020-09-08

Abstract excerpt

<h4>Background</h4> The pig has long been an important animal species for biomedical research. Recent years has also seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele which carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53 R167H (orthologous to human TP53 R17...

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Literature Corpus work: 4c725d27-3a51-52c9-b41f-663e1fe83786
DOI: 10.1101/2020.09.07.286005

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