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Article

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers.

Pharmacogenetics and genomics - 1 Jul 2012

Lee Wonho, Ray Riju, Bergen Andrew W, Swan Gary E, Thomas Paul, Tyndale Rachel F, Benowitz Neal L, Lerman Caryn, Conti David V

Abstract excerpt

Nicotine metabolism and genetic variation have an impact on nicotine addiction and smoking abstinence; however, further research is required. The nicotine metabolite ratio (NMR) is a robust biomarker of nicotine metabolism used to categorize slow and normal nicotine metabolizers (lower 25th quartile cut off). In two randomized clinical trials of smoking abstinence treatments, we conducted NMR-stratified analyses...

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Topics

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Share to DRD1 gene
Share to Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nicotine

Share to Polymorphism, Single Nucleotide

Share to Receptors, Dopamine D1

Share to Smoking

Share to Smoking Cessation

Share to Tobacco Use Disorder

Source

Open in PubMed Open full text

Identifiers

PMID: 22495174
DOI: 10.1097/FPC.0b013e3283539062
PMCID: PMC3376177

Genes

DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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