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Article

Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.

The Journal of biological chemistry - 23 Apr 2010

Furuita Kyoko, Jee JunGoo, Fukada Harumi, Mishima Masaki, Kojima Chojiro

Abstract excerpt

Oxysterol-binding protein (OSBP), a cytosolic receptor of cholesterol and oxysterols, is recruited to the endoplasmic reticulum by binding to the cytoplasmic major sperm protein (MSP) domain of integral endoplasmic reticulum protein VAMP-associated protein-A (VAP-A), a process essential for the stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. To delineate the interaction mechanism between VAP-A...

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Identifiers

PMID: 20178991
DOI: 10.1074/jbc.M109.082602
PMCID: PMC2857075

Genes

OSBP

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