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Article

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.

Nucleic acids research - 1 Aug 2011

Seizl Martin, Larivière Laurent, Pfaffeneder Toni, Wenzeck Larissa, Cramer Patrick

Abstract excerpt

Mediator is a multiprotein co-activator of RNA polymerase (Pol) II transcription. Mediator contains a conserved core that comprises the 'head' and 'middle' modules. We present here a structure-function analysis of the essential Med11/22 heterodimer, a part of the head module. Med11/22 forms a conserved four-helix bundle domain with C-terminal extensions, which bind the central head subunit Med17. A highly...

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Identifiers

PMID: 21498544
DOI: 10.1093/nar/gkr229
PMCID: PMC3152362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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