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Article

Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.

Science (New York, N.Y.) - 28 Aug 1998

de Beer T, Carter R E, Lobel-Rice K E, Sorkin A, Overduin M

Abstract excerpt

Eps15 homology (EH) domains are eukaryotic signaling modules that recognize proteins containing Asn-Pro-Phe (NPF) sequences. The structure of the central EH domain of Eps15 has been solved by heteronuclear magnetic resonance spectroscopy. The fold consists of a pair of EF hand motifs, the second of which binds tightly to calcium. The NPF peptide is bound in a hydrophobic pocket between two alpha helices, and...

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Identifiers

PMID: 9721102
DOI: 10.1126/science.281.5381.1357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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