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Article

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.

Nature communications - 10 Mar 2017

Emmanouilidis Leonidas, Schütz Ulrike, Tripsianes Konstantinos, Madl Tobias, Radke Juliane, Rucktäschel Robert, Wilmanns Matthias, Schliebs Wolfgang, Erdmann Ralf, Sattler Michael

Abstract excerpt

The transport of peroxisomal membrane proteins (PMPs) requires the soluble PEX19 protein as chaperone and import receptor. Recognition of cargo PMPs by the C-terminal domain (CTD) of PEX19 is required for peroxisome biogenesis in vivo. Farnesylation at a C-terminal CaaX motif in PEX19 enhances the PMP interaction, but the underlying molecular mechanisms are unknown. Here, we report the NMR-derived structure of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28281558
DOI: 10.1038/ncomms14635
PMCID: PMC5353646

Genes

PEX19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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