Article
The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members.
Nucleic acids research - 1 May 2013
Verger Alexis, Baert Jean-Luc, Verreman Kathye, Dewitte Frédérique, Ferreira Elisabeth, Lens Zoé, de Launoit Yvan, Villeret Vincent, Monté Didier
Abstract excerpt
PEA3, ERM and ER81 belong to the PEA3 subfamily of Ets transcription factors and play important roles in a number of tissue-specific processes. Transcriptional activation by PEA3 subfamily factors requires their characteristic amino-terminal acidic transactivation domain (TAD). However, the cellular targets of this domain remain largely unknown. Using ERM as a prototype, we show that the minimal N-terminal TAD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.