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Article

PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Human molecular genetics - 15 Sept 2015

Chou Ching-Chieh, Alexeeva Olga M, Yamada Shizuka, Pribadi Amy, Zhang Yi, Mo Bi, Williams Kathryn R, Zarnescu Daniela C, Rossoll Wilfried

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a major disease protein in amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases. Both the cytoplasmic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments and the loss of normal TDP-43 from the nucleus may contribute to the disease progression by impairing normal RNA and protein homeostasis. Therefore, both the removal of...

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Share to Proteasome Endopeptidase Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Interaction Mapping

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Source

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Identifiers

PMID: 26130692
DOI: 10.1093/hmg/ddv238
PMCID: PMC4550816

Genes

PABPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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