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"STRESSED OUT": The role of FUS and TDP-43 in amyotrophic lateral sclerosis.

The international journal of biochemistry & cell biology - 1 Sept 2020

Aksoy Yagiz Alp, Deng Wei, Stoddart Jack, Chung Roger, Guillemin Gilles, Cole Nicholas James, Neely Graham Gregory, Hesselson Daniel

Abstract excerpt

Mutations in fused-in-sarcoma (FUS) and TAR DNA binding protein-43 (TDP-43; TARDBP) are known to cause the severe adult-onset neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Proteinopathy caused by cellular stresses such as endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial stress and proteasomal stress and the formation of stress granules (SGs), cytoplasmic aggregates and...

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Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Research
Cytosol
DNA-Binding Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurogenetic and Muscular Disorders Research

Prion Diseases and Protein Misfolding

RNA-Binding Protein FUS

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PMID: 32758633
DOI: 10.1016/j.biocel.2020.105821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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