Article

Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis

2019-02-25

Abstract excerpt

TDP-43 is an RNA-binding protein that forms cytoplasmic aggregates in multiple neurodegenerative diseases. Although the loss of normal TDP-43 functions likely contributes to disease pathogenesis, the cell biological consequences of human TDP-43 depletion are not well understood. We therefore generated human TDP-43 knockout cells and subjected them to parallel cell biological and transcriptomic analyses. These effo...

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Literature Corpus work: a9ad127d-4d06-5f58-b544-3141bd643459
DOI: 10.1101/560144

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