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Article

Molecular, functional, and pathological aspects of TDP-43 fragmentation

21 Apr 2021

Abstract excerpt

Transactive response DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and...

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PMID: 34013172
DOI: 10.1016/j.isci.2021.102459

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