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Cytoplasmic TDP-43 is involved in cell fate during stress recovery

4 Aug 2021

Abstract excerpt

Transactive response DNA binding protein 43 (TDP-43) is an RNA processing protein central to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Nuclear TDP-43 mislocalizes in patients to the cytoplasm, where it forms ubiquitin-positive inclusions in affected neurons and glia. Physiologically, cytoplasmic TDP-43 is associated with stress granules (SGs). Here, we explored...

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PMID: 34378050
DOI: 10.1093/hmg/ddab227

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