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Proteomics Analysis of the TDP ‐43 Interactome in Cellular Models of ALS Pathogenesis

1 May 2025

Abstract excerpt

ABSTRACT Cytoplasmic aggregation and nuclear depletion of TAR DNA‐binding protein 43 (TDP‐43) is a hallmark pathology of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and limbic‐predominant age‐related TDP‐43 encephalopathy (LATE). However, the protein interactome of TDP‐43 remains incompletely defined. In this study, we aimed to...

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PMID: 40365763
DOI: 10.1111/jnc.70079

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