Article
Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.
PloS one - 11 Oct 2010
Liu-Yesucevitz Liqun, Bilgutay Aylin, Zhang Yong-Jie, Vanderweyde Tara, Vanderwyde Tara, Citro Allison, Mehta Tapan, Zaarur Nava, McKee Ann, Bowser Robert, Sherman Michael, Petrucelli Leonard, Wolozin Benjamin
Abstract excerpt
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, but in affected areas of ALS and FTLD-U central nervous system, TDP-43 is aberrantly processed and forms cytoplasmic inclusions. The mechanisms governing TDP-43 inclusion formation are poorly...
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