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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins

26 Sept 2016

Abstract excerpt

TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). For the purpose of this study we...

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PMID: 27665936
DOI: 10.1038/srep33996

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