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Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli

30 Jun 2015

Abstract excerpt

UNLABELLED: Uropathogenic Escherichia coli (UPEC) is the primary cause of community-acquired urinary tract infections (UTIs). UPEC bind the bladder using type 1 pili, encoded by the fim operon in nearly all E. coli. Assembled type 1 pili terminate in the FimH adhesin, which specifically binds to mannosylated glycoproteins on the bladder epithelium. Expression of type 1 pili is regulated in part by phase-variable...

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PMID: 26126855
DOI: 10.1128/mbio.00820-15

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