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Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic <i>Escherichia coli</i> virulence determinants in the murine urinary tract

1 Aug 2002

Abstract excerpt

Escherichia coli is the leading cause of urinary tract infections (UTIs). Despite the association of numerous bacterial factors with uropathogenic E. coli (UPEC), few such factors have been proved to be required for UTI in animal models. Previous investigations of urovirulence factors have relied on prior identification of phenotypic characteristics. We used signature-tagged mutagenesis (STM) in an unbiased...

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PMID: 12180926
DOI: 10.1046/j.1365-2958.2002.03078.x

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