Article
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers.
PLoS genetics - 1 Jun 2015
Stewart James B, Alaei-Mahabadi Babak, Sabarinathan Radhakrishnan, Samuelsson Tore, Gorodkin Jan, Gustafsson Claes M, Larsson Erik
Abstract excerpt
Somatic mutations in the nuclear genome are required for tumor formation, but the functional consequences of somatic mitochondrial DNA (mtDNA) mutations are less understood. Here we identify somatic mtDNA mutations across 527 tumors and 14 cancer types, using an approach that takes advantage of evidence from both genomic and transcriptomic sequencing. We find that there is selective pressure against deleterious...
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