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Article

Intratumoural heterogeneity may hinder precision medicine strategies in patients with clear cell renal cell carcinoma.

Journal of clinical pathology - 1 May 2018

Raspollini Maria Rosaria, Montagnani Ilaria, Montironi Rodolfo, Castiglione Francesca, Martignoni Guido, Cheng Liang, Lopez-Beltran Antonio

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is an heterogeneous tumour at architectural, cellular and molecular level, a reason why the 2014 International Society of Urological Pathology consensus recommended wide sampling of RCC masses to include at least 1 block/cm of tumour together with perpendicular sections of the tumour/perinephric fat interface and the tumour/renal sinus interface. Intratumoural molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29317515
DOI: 10.1136/jclinpath-2017-204931

Genes

ALK
BRAF
DDR2
EGFR
ERBB2
KRAS
NRAS
RET

Provenance

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