Article
Backbone resonance assignments of ferric human cytochrome c and the pro-apoptotic G41S mutant in the ferric and ferrous states.
Biomolecular NMR assignments - 1 Oct 2015
Karsisiotis Andreas Ioannis, Deacon Oliver M, Rajagopal Badri S, Macdonald Colin, Blumenschein Tharin M A, Moore Geoffrey R, Worrall Jonathan A R
Abstract excerpt
Human cytochrome c is a multi-functional protein with key roles in both the mitochondrial electron transfer chain and in apoptosis. In the latter, a complex formed between the mitochondrial phospholipid cardiolipin and cytochrome c is crucial for instigating the release of pro-apoptotic factors, including cytochrome c, from the mitochondrion into the cytosol. The G41S mutant of human cytochrome c is the only...
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