Article
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2017
Moreno-Beltrán Blas, Guerra-Castellano Alejandra, Díaz-Quintana Antonio, Del Conte Rebecca, García-Mauriño Sofía M, Díaz-Moreno Sofía, González-Arzola Katiuska, Santos-Ocaña Carlos, Velázquez-Campoy Adrián, De la Rosa Miguel A, Turano Paola, Díaz-Moreno Irene
Abstract excerpt
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer. Although cytochrome c phosphorylation-in particular, at tyrosine 48-is a key modulator of mitochondrial signaling, its action and molecular basis remain unknown. Here we mimic phosphorylation of cytochrome c by...
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