Article

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity

2020-06-15

Abstract excerpt

Mutation of cytochrome c in humans causes mild autosomal dominant thrombocytopenia. The role of cytochrome c in platelet formation, and molecular mechanism underlying the association of cytochrome c mutations with thrombocytopenia remains unknown, although a gain-of-function is most likely. Cytochrome c contributes to several cellular processes, with exchange between conformational states proposed to regulate...

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Literature Corpus work: 6a96691f-da30-5518-9ea0-3a79e8fe741c
DOI: 10.1101/2020.06.14.151373

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