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Article

Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.

The Biochemical journal - 1 Mar 2014

Josephs Tracy M, Morison Ian M, Day Catherine L, Wilbanks Sigurd M, Ledgerwood Elizabeth C

Abstract excerpt

The peroxidase activity of cytochrome c may play a key role in the release of cytochrome c from the mitochondrial intermembrane space in the intrinsic apoptosis pathway. Induction of the peroxidase activity of cytochrome c is ascribed to partial unfolding and loss of axial co-ordination between the haem Fe and Met80, and is thought to be triggered by interaction of cytochrome c with cardiolipin...

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Identifiers

PMID: 24329121
DOI: 10.1042/BJ20131386

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Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.PMID 24329121Read ↗

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