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Article

Distal Unfolding of Ferricytochrome c Induced by the F82K Mutation.

International journal of molecular sciences - 20 Mar 2020

Lalli Daniela, Rosa Camilla, Allegrozzi Marco, Turano Paola

Abstract excerpt

It is well known that axial coordination of heme iron in mitochondrial cytochrome c has redox-dependent stability. The Met80 heme iron axial ligand in the ferric form of the protein is relatively labile and can be easily replaced by alternative amino acid side chains under non-native conditions induced by alkaline pH, high temperature, or denaturing agents. Here, we showed a redox-dependent destabilization...

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Identifiers

PMID: 32244917
DOI: 10.3390/ijms21062134
PMCID: PMC7139943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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