Article
Increased dynamics in the 40-57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation.
Scientific reports - 27 Jul 2016
Karsisiotis Andreas Ioannis, Deacon Oliver M, Wilson Michael T, Macdonald Colin, Blumenschein Tharin M A, Moore Geoffrey R, Worrall Jonathan A R
Abstract excerpt
Thrombocytopenia 4 is an inherited autosomal dominant thrombocytopenia, which occurs due to mutations in the human gene for cytochrome c that results in enhanced mitochondrial apoptotic activity. The Gly41Ser mutation was the first to be reported. Here we report stopped-flow kinetic studies of azide binding to human ferricytochrome c and its Gly41Ser variant, together with backbone amide H/D exchange and...
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