Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study.

Neuroscience - 15 Dec 2019

Thomas Mitha, Ranjith G, Radhakrishnan Ashalatha, Arun Anirudhan V

Abstract excerpt

Several reports of augmented hyperpolarisation-activated cyclic nucleotide-gated (HCN) currents in seizures have suggested a pro-convulsive identity for HCN channels. The mutations identified in one or more of the four HCN channel subunits are found to be contributing to different epileptic phenotypes. S126L, S632W, V246M and E515K are four different mutations affecting the HCN2 subunit and have been reported in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to CA1 Region, Hippocampal
Share to Dendrites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Share to Models, Neurological

Share to Neuronal Plasticity

Share to Pyramidal Cells

Share to Receptors, Glutamate

Source

Identifiers

PMID: 31682955
DOI: 10.1016/j.neuroscience.2019.10.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study.PMID 31682955Read ↗

Novel HCN1 Mutations Associated With Epilepsy and Impacts on Neuronal ExcitabilitySemantic proximity Read ↗

Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy.Semantic proximity Read ↗

HCN and KV7 (M-) channels as targets for epilepsy treatment.Semantic proximity Read ↗

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.Semantic proximity Read ↗

Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits.Semantic proximity Read ↗

HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.Semantic proximity Read ↗

Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.Semantic proximity Read ↗

Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neuronsSemantic proximity Read ↗

Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.Semantic proximity Read ↗

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.Semantic proximity Read ↗

HCN2‐Associated Neurodevelopmental Disorders: Data from Patients and Xenopus Cell ModelsSemantic proximity Read ↗

Biological science of headache channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.