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Article

Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.

PloS one - 1 Jan 2013

Nakamura Yuki, Shi Xiuyu, Numata Tomohiro, Mori Yasuo, Inoue Ryuji, Lossin Christoph, Baram Tallie Z, Hirose Shinichi

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated currents, known as I h, are involved in the control of rhythmic activity in neuronal circuits and in determining neuronal properties including the resting membrane potential. Recent studies have shown that HCN channels play a role in seizure susceptibility and in absence and limbic epilepsy including temporal lobe epilepsy following long...

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Source

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Identifiers

PMID: 24324597
DOI: 10.1371/journal.pone.0080376
PMCID: PMC3851455

Genes

HCN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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