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Article

HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.

British journal of pharmacology - 1 Jan 2012

Reid Christopher A, Phillips A Marie, Petrou Steven

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN) can act as pacemakers in the brain making them strong candidates for driving aberrant hypersynchronous network activity seen in epilepsy. Transcriptional changes in HCN channels occur in several animal models of epilepsy. However, only recently have genetic studies demonstrated sequence variation in HCN1 and HCN2 genes associated with human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21615728
DOI: 10.1111/j.1476-5381.2011.01507.x
PMCID: PMC3252965

Genes

HCN2
HCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.PMID 21615728Read ↗

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