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Article

cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.

Circulation. Arrhythmia and electrophysiology - 1 Oct 2010

Schweizer Patrick A, Duhme Nana, Thomas Dierk, Becker Rüdiger, Zehelein Jörg, Draguhn Andreas, Bruehl Claus, Katus Hugo A, Koenen Michael

Abstract excerpt

BACKGROUND: HCN channels activate the pacemaker current I(f), which is thought to contribute significantly to generation and regulation of heart rhythm. HCN4 represents the dominant isotype in the sinoatrial node and binding of cAMP was suggested to be necessary for autonomic heart rate regulatio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic Nucleotide-Gated Cation Channels

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Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

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Source

Identifiers

PMID: 20693575
DOI: 10.1161/CIRCEP.110.949768

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20693575-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.PMID 20693575Read ↗

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