Article
Functional POR A503V is associated with the risk of bladder cancer in a Chinese population.
Scientific reports - 30 Jun 2015
Xiao Xue, Ma Gaoxiang, Li Shushu, Wang Meilin, Liu Nian, Ma Lan, Zhang Zhan, Chu Haiyan, Zhang Zhengdong, Wang Shou-Lin
Abstract excerpt
Human cytochrome P450 oxidoreductase (POR) plays important roles in the metabolism of exogenous carcinogens and endogenous sterol hormones. However, few studies have explored the association between POR variants and the risk of bladder cancer. In this study, we first sequenced all 16 POR exons among 50 randomly selected controls, and found three variants, rs1135612, rs1057868 (A503V) and rs2228104, which were...
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