Article
CYP1B1 gene polymorphisms correlate with an increased risk of urinary bladder cancer in India.
Urologic oncology - 1 Apr 2016
Sankhwar Monica, Sankhwar Satya Narayan, Abhishek Amar, Gupta Nishi, Rajender Singh
Abstract excerpt
PURPOSE: The urinary bladder is the target of several toxic compounds, which makes the bladder more prone to cancer. Cytochrome P450 1B1 enzyme is present in tumor tissues and metabolizes the polyaromatic carcinogens and activates several procarcinogens that cause DNA damage. We examined the functional single-nucleotide polymorphisms in the CYP1B1 gene to study their association with the urinary bladder cancer....
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