Article
Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer.
Human molecular genetics - 15 Apr 2012
Tang Wei, Fu Yi-Ping, Figueroa Jonine D, Malats Núria, Garcia-Closas Montserrat, Chatterjee Nilanjan, Kogevinas Manolis, Baris Dalsu, Thun Michael, Hall Jennifer L, De Vivo Immaculata, Albanes Demetrius, Porter-Gill Patricia, Purdue Mark P, Burdett Laurie, Liu Luyang, Hutchinson Amy, Myers Timothy, Tardón Adonina, Serra Consol, Carrato Alfredo, Garcia-Closas Reina, Lloreta Josep, Johnson Alison, Schwenn Molly, Karagas Margaret R, Schned Alan, Black Amanda, Jacobs Eric J, Diver W Ryan, Gapstur Susan M, Virtamo Jarmo, Hunter David J, Fraumeni Joseph F, Chanock Stephen J, Silverman Debra T, Rothman Nathaniel, Prokunina-Olsson Ludmila
Abstract excerpt
A recent genome-wide association study of bladder cancer identified the UGT1A gene cluster on chromosome 2q37.1 as a novel susceptibility locus. The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and removal of aromatic amines. Bioactivated forms of aromatic amines found in tobacco smoke and industrial chemicals are the main risk factors for bladder...
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