Article
A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males.
Journal of human genetics - 1 Aug 2011
Ratanajaraya Chanavee, Nishiyama Hiroyuki, Takahashi Meiko, Kawaguchi Takahisa, Saito Ryoichi, Mikami Yoshiki, Suyama Mikita, Lathrop Mark, Yamada Ryo, Ogawa Osamu, Matsuda Fumihiko
Abstract excerpt
Urinary bladder cancer (UBC) is a common cancer with male predominance. Pathologically it is classified into two distinct tumor entities related to the risk of patients. The low-grade tumors with relatively well-differentiated tumor histology (G1 and G2) at stage Ta are non-invasive and pose a minimal risk, whereas high-grade tumors (G2 and G3) with stages T1 to T4 are aggressive with invasion, and therefore,...
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