Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and <i>Wnt </i>Pathway in the Intestine of Apc^+/1638N Mice: Comparisons and Contrasts

Abstract excerpt

Obesity is an established risk factor for colorectal cancer (CRC). Our previous study indicated that obesity increases activity of the pro-tumorigenic Wnt-signaling. Presently, we sought to further advance our understanding of the mechanisms by which obesity promotes CRC by examining associations between microbiome, inflammation and Wnt-signaling in Apc +/1638N mice whose obesity was induced by one of two...

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