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Article

Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation.

BMC cancer - 29 Jun 2020

Moskowitz Jacob E, Doran Anthony G, Lei Zhentian, Busi Susheel B, Hart Marcia L, Franklin Craig L, Sumner Lloyd W, Keane Thomas M, Amos-Landgraf James M

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a multifactorial disease resulting from both genetic predisposition and environmental factors including the gut microbiota (GM), but deciphering the influence of genetic variants, environmental variables, and interactions with the GM is exceedingly difficult. We previously observed significant differences in intestinal adenoma multiplicity between C57BL/6 J-ApcMin (B6-Min/J)...

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Identifiers

PMID: 32600361
DOI: 10.1186/s12885-020-07007-9
PMCID: PMC7322931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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