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Modeling Fusobacterium nucleatum-Driven Colorectal Cancer in Apc-Mutant Mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Han Bing, Liu Wei, Chen Yimin, Chen Yi-Wei, Ton-That Hung, Chang Jia, Wang Cun-Yu

Abstract excerpt

Colorectal cancer (CRC) typically initiates with mutations in the adenomatous polyposis coli (Apc) gene, followed by the influence of environmental factors. Among these, Fusobacterium nucleatum has emerged as an important CRC-enriched microbial species with demonstrated tumor-promoting potential. To investigate the contribution of F. nucleatum in the context of oncogenic mutations, physiologically relevant mouse...

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PMID: 42613577
DOI: 10.1007/978-1-0716-5388-3_19

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