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Functional Connection between Rad51 and PML in Homology-Directed Repair

5 Oct 2011

Abstract excerpt

The promyelocytic leukemia protein (PML) is a tumor suppressor critical for formation of nuclear bodies (NBs) performing important functions in transcription, apoptosis, DNA repair and antiviral responses. Earlier studies demonstrated that simian virus 40 (SV40) initiates replication near PML NBs. Here we show that PML knockdown inhibits viral replication in vivo, thus indicating a positive role of PML early in...

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Identifiers

PMID: 21998700
DOI: 10.1371/journal.pone.0025814

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