Article
Towards allele-level human leucocyte antigens genotyping - assessing two next-generation sequencing platforms: Ion Torrent Personal Genome Machine and Illumina MiSeq.
International journal of immunogenetics - 1 Oct 2015
Duke J L, Lind C, Mackiewicz K, Ferriola D, Papazoglou A, Derbeneva O, Wallace D, Monos D S
Abstract excerpt
Human leucocyte antigens (HLA) typing has been a challenge due to extreme polymorphism of the HLA genes and limitations of the current technologies and protocols used for their characterization. Recently, next-generation sequencing techniques have been shown to be a well-suited technology for the complete characterization of the HLA genes. However, a comprehensive assessment of the different platforms for HLA...
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