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The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.

Fungal genetics and biology : FG & B - 1 Sept 2015

Wang Betsy, Li Kristin, Jin Max, Qiu Rongde, Liu Bo, Oakley Berl R, Xiang Xin

Abstract excerpt

Centrosome amplification is a hallmark of many types of cancer cells, and clustering of multiple centrosomes is critical for cancer cell survival and proliferation. Human kinesin-14 HSET/KFIC1 is essential for centrosome clustering, and its inhibition leads to the specific killing of cancer cells with extra centrosomes. Since kinesin-14 motor domains are conserved evolutionarily, we conceived a strategy of...

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Identifiers

PMID: 26117688
DOI: 10.1016/j.fgb.2015.06.005
PMCID: PMC4554971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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