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Article

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis.

PLoS genetics - 1 Oct 2016

Polvi Elizabeth J, Averette Anna F, Lee Soo Chan, Kim Taeyup, Bahn Yong-Sun, Veri Amanda O, Robbins Nicole, Heitman Joseph, Cowen Leah E

Abstract excerpt

Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance. Defining circuitry controlling these traits opens new opportunities for chemical diversity in therapeutics, as the cognate inhibitors are rarely explored by conventional screening approaches. This has great potential to address the pressing need for new...

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Identifiers

PMID: 27695031
DOI: 10.1371/journal.pgen.1006350
PMCID: PMC5047589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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